Jaundice is a yellow discoloration of the skin and eyes resulting
from high levels of bilirubin in the blood (hyperbilirubinemia) and tissue
caused by normal or accelerated breakdown of red blood cells.
Jaundice typically occurs within the first few days of
life and in most cases is benign.
Because of the potential toxicity of bilirubin, newborn
infants must be monitored to identify those
who might develop severe
hyperbilirubinemia and, in rare cases, acute bilirubin encephalopathy or
Jaundice is the most common health condition requiring
medical attention in newborns, typically phototherapy or blood
There are two types of jaundice: direct and indirect
Phototherapy treats indirect hyperbilirubinemia.
Discovered in 50’s and 60’s, phototherapy chemically
changes billirubin molecules to a water-soluble form as light penetrates skin
Changed molecules enter the liver cell are:
Some of these new molecules can be changed back to
their original form.