Overview

TRACERlab FX2 MeI


The TRACERlab FX2 MeI, evolution of the TRACERlab FX MeI, is a fully automated system for easy and efficient production of [11C] methyl iodide or [11C] methyl triflate, both precursors for many important [11C] tracers.

TRACERlab FX2 MeI combines flexibility and productivity. It provides a patented gas phase [11C] methyl iodide production method via direct reaction of Iodine with [11C] methane. [11C] methane can either be supplied from a [11C] methane target or in case a [11C]CO2 target is used, the integrated conversion step of [11C]CO2 to [11C] methane can be utilized.

More than 50 tracers have been produced and published using TRACERlab FX C Pro and the couple TRACERlab FX2 MeI / TRACERlab FX2 M can run all these synthesis methods too.


TRACERlab FX2 M


The TRACERlab FX2 M, evolution of the TRACERlab FX M, is a fully automated system for easy and efficient production of [11C] tracers starting with a suitable [11C] precursor like [11C] methyl iodide or [11C] methyl triflate. A typical synthesis system combines between one and four TRACERlab FX2 M modules with one TRACERlab FX2 MeI module that delivers the [11C] precursor.

TRACERlab FX2 M combines flexibility and productivity. It allows to produce [11C] tracers starting with [11C] methyl iodide or [11C] methyl triflate.

More than 50 tracers have been produced and published using TRACERlab FX C Pro and the couple TRACERlab FX2 MeI / TRACERlab FX2 M can run all these synthesis methods too.

TRACERlab FX M

Benefits

High Performance and Reliability

TRACERlab FX2 MeI and FX2 M are designed to help you:

  • Achieve high yield
  • Increase productivity with easy-to-use operation
  • Improve cost-efficiency by using just one FX2 MeI to feed up to four FX2 M modules
  • Formulate final solution
  • Minimize radioactivity
  • Program easily for customization and flexibility
  • Save time by modifying processes with just a few keystrokes
  • Reduce need for reagents; FX2 MeI reagents last six to ten runs
  • Perform back-to-back [11C]-methyl iodide runs
  • Transfer precursor automatically from FX2 MeI to FX2 M

 

Technology

TRACERlab FX2 MeI:

The TRACERlab FX2 MeI integrates all the necessary steps for the production of [11C] methyl iodide or [11C] methyl triflate.

  • Trapping of [11C]-carbon dioxide or [11C]-methane,
  • Patented gas-phase synthesis of [11C]methyl iodide and [11C] methyl triflate with high specific activity,
  • Conversion to methyl iodide,
  • Optional conversion to methyl triflate,
  • Optional [11C]-carbon dioxide concentration for further rapid processing of carboxylation reactions,
  • Gas system sealed against room air.

All production steps are fully automated.

For production of a final tracer up to four TRACERlab FX2 M can be connected to the TRACERlab FX2 MeI. Also other methylation units like TRACERlab FX M can be connected.


TRACERlab FX2 M:

The TRACERlab FX2 M integrates all the necessary steps for the production of [11C] tracers:

  • Labeling reactor with heating, cooling and stirring features
  • Build-in semipreparative HPLC purification
  • Build-in formulation of the final tracer
  • Gas and liquid system sealed against room air

All production steps are fully automated.

The semi-preparative radio-HPLC system comprises an injection valve, a semi-preparative HPLC column, a radioactivity flow-through detector, an UV detector and a fraction collector valve to isolate the final tracer.

 

Specifications

TRACERlab FX2 MeI:

Configuration   Performance    
Cyclotron Target [11C]MeI Yield [11C]MeI specific activityA [GBq/µmol] Intrinsic formation of cold MeI [nmol/run]
PETtrace CH4 37% ± 7% 1000B < 20
PETtrace CO2 37% ± 7%A 400B C < 25

A Using purifiers for target gases input

B Indicative values only, valid in combination with GE PETtrace cyclotron, not suitable for acceptance

C At 75 GBq (2 Ci) [11C]CO2.

Back-to back cycle time for Mel production < 30 min
Number of runs w/o refilling Iodine at least 6

System Characteristics

Size (W x H x D) of main module 29 cm x 48 cm x 37 cm
Weight of main module 25 kg
Control electronics 29 cm x 21 cm x 8.5 cm
3 Radiation detectors [11C]CO2, [11C]CH4, [11C]MeI
Outputs to labelling unit 4, switchable by the control computer


TRACERlab FX2 M:

System Characteristics

Size (W x H x D) of main module 34 cm x 48 cm x 37 cm
Weight of main module 15 kg
Control electronics 29 cm x 21 cm x 8.5 cm
3 Radiation detectors Reactor, HPLC, produce vial
Labelling reactor Borosilicate glass, 9 mm ID, v-shape, magnetic stirrer, heating up to 200°C, cooling down to -100°C. Retractable reactor needle.
Reagent vials 4 for the labelling reactor
3 for the formulation subsystem
Purification subsystem Isocratic HPLC controlled by the synthesis software
Gamma radiation and UV (190-500 nm D2) detectors
Formulation subsystem Solid phase extraction with stirred dilution flask